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High throughput, large field of view structural imaging with SCAPE 2.0 Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Versatile whole-organ-body staining and imaging based on electrolyte-gel properties of biological tissues Fixed mouse cerebellar brain section, 300 μm Neurons Beta lobe neurons Optic Lobe of Drosophila Brain Neurons from a mouse spinal cord Signaling in neurons Hippocampal neurons Neurons and Nipah Virus Proteins Zebrafish Locus Coeruleus Shooting stars enlighten intrathalamic plasticity Hippocampal neuron receiving excitatory contacts Fluorescence image of a neuron labeled for synapses (green) and cell structure (magenta) Scanning electron micrograph (false color) of a human induced pluripotent stem cell-derived neuron Cultured neuron with radiating dendrites Brainbow mouse hippocampus The axons and dendrites of a cortical neuron Phaloidin-Atto647N stain of actin in a cultured hippocampal neuron Quadruple whole-cell patch clamp in visual cortex Hippocampal fast-spiking (FS) basket cell (BC) Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline Vital Staining of Adult Neuromuscular Junctions in a thy1-YFP Transgenic Mouse Expression of XFP in the Hippocampus and Cerebral Cortex CLARITY mouse hippocampus Labeled ganglion cells in the mouse retina Patch clamped layer 5 pyramidal neurons in visual cortex with a fluorescent dye under a 2-photon laser scanning microscope Neuronal culture Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip Transistor Probes Local Potassium Conductances in the Adhesion Region of Cultured Rat Hippocampal Neurons Dentate gyrus granule neurons Adult mouse hippocampus Osmium tetroxide stained transmission electron micrograph of the many layers of membrane in myelin Hippocampal growth cones making contact Two hippocampal growth cones making a connection [more] [more]
Animated BrainBow CUBIC-HV Fluorescent Myelin Populations Recording and Manipulation Single Cells Synapses

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c-Fos stained mouse brain sagittal sections for saline group (left) and MK-801 group (right).


Citation

Etsuo A. Susaki, Chika Shimizu, Akihiro Kuno, Kazuki Tainaka, Xiang Li, Kengo Nishi, Ken Morishima, Hiroaki Ono, Koji L. Ode, Yuki Saeki, Kazunari Miyamichi, Kaoru Isa, Chihiro Yokoyama, Hiroki Kitaura, Masako Ikemura, Tetsuo Ushiku, Yoshihiro Shimizu, Takashi Saito, Takaomi C. Saido, Masashi Fukayama, Hirotaka Onoe, Kazushige Touhara, Tadashi Isa, Akiyoshi Kakita, Mitsuhiro Shibayama and Hiroki R. Ueda (2020). Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues. Nature Communications 11:1982. DOI:10.1038/s41467-020-15906-5


Location

Japan


Technique

CUBIC-HV


Press release

Press release (RIKEN)